IL17A

IL17A

Interleukin 17A
Available structures
PDB Ortholog search: RCSB
Identifiers
IL17A Gene
RNA expression pattern

Interleukin-17A is a protein that in humans is encoded by the IL17A gene.[1][2]

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.[2]

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.