Cardiobacterium hominis

Cardiobacterium hominis

Cardiobacterium hominis
Cardiobacterium hominis on blood agar plate
Scientific classification
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Cardiobacteriales
Family: Cardiobacteriaceae
Genus: Cardiobacterium
Species: hominis

Cardiobacterium hominis is a Gram-negative rod commonly grouped with other bacteria into the HACEK group. It is one of several bacteria normally present in the mouth and upper part of the respiratory tract such as nose and throat. However, it may also rarely cause endocarditis, an infection of the heart valves.[1]


C. hominis is a catalase-negative, oxidase-positive, indole-producing Gram-negative rod.[2] Its morphology has classically been described as highly pleomorphic and irregularly staining, although homogeneous bacilli with uniform shapes may be seen with the addition of yeast extract.[2]

Antibiotic sensitivity

Historically C. hominis has been sensitive to trimethoprim-sulfamethoxazole, fluoroquinolones, and aztreonam.[3] C. hominis is often resistant to erythromycin.[5] Since cefotaxime use may be not appropriate for C. hominis endocarditis, an alternative regimen might include association of co-amoxiclav and gentamicin.[6]


  1. ^ Malani AN, Aronoff DM, Bradley SF, Kauffman CA (September 2006). "Cardiobacterium hominis endocarditis: Two cases and a review of the literature". European Journal of Clinical Microbiology & Infectious Diseases 25 (9): 587–95.  
  2. ^ a b Savage DD, Kagan RL, Young NA, Horvath AE (January 1977). "Cardiobacterium hominis endocarditis: description of two patients and characterization of the organism". Journal of Clinical Microbiology 5 (1): 75–80.  
  3. ^ a b c Wilson WR, Karchmer AW, Dajani AS, et al. (December 1995). "Antibiotic treatment of adults with infective endocarditis due to streptococci, enterococci, staphylococci, and HACEK microorganisms. American Heart Association". JAMA 274 (21): 1706–13.  
  4. ^ Lu PL, Hsueh PR, Hung CC, Teng LJ, Jang TN, Luh KT (May 2000). "Cardiobacterium hominis"Infective endocarditis complicated with progressive heart failure due to beta-lactamase-producing . Journal of Clinical Microbiology 38 (5): 2015–7.  
  5. ^ Michael A. Pfaller; Murray, Patrick R.; Rosenthal, Ken S. (2009). Medical microbiology. Philadelphia: Mosby / Elsevier. p. 374.  
  6. ^ Torok E et al. Oxford Handbook Infect Dis and Microbiol. 2009

External links

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