|Classification and external resources|
|ICD-10||A44.0 (ILDS A44.800)|
In 1875 an outbreak, characterized by fever and anemia occurred in the region of construction of the railroad line between Lima and Oroya. This is the source of the name "oroya fever" sometimes used to describe acute bartonellosis.
In August 1885, Daniel Alcides Carrión, a Peruvian medical student, attempted to inoculate himself with material taken from a verruga lesion of a chronic patient (Carmen Paredes), with the help of a local physician (Evaristo Chavez). After 3 weeks he developed classic symptoms of the acute phase of the disease, thus establishing a common etiology (cause) for these two diseases. He died from bartonellosis on October 5, 1885 and was recognized as a martyr of Peruvian medicine and the term Carrión's Disease was used until our times (Peruvian Medicine Day is October 5 in honor to him).
Alberto Barton, a Peruvian microbiologist, identified Bartonella bacilliformis within erythrocytes in 1905, an announced the discovery of the etiologic agent (Barton bacillus) in 1909, which was called Bartonella bacilliformis.
It is caused by Bartonella bacilliformis. Recent investigations show that Candidatus Bartonella ancashi may cause verruga peruana, although it may not meet all of Koch's postulates. There is no experimental reproduction of the Peruvian wart in animals. Science needs to base its conclusions on the best available evidence.
Carrion's disease is found only in Peru, Ecuador, and Colombia. It is endemic in some areas of Peru and is caused by infection with the bacterium Bartonella bacilliformis and transmitted by sandflies of genus Lutzomyia.
Clinical signs and symptoms
The clinical symptoms of bartonellosis are pleomorphic and some patients from endemic areas may be asymptomatic. The two classical clinical presentations are the acute phase and the chronic phase, corresponding to the two different host cell types invaded by the bacterium (red blood cells and endothelial cells).
Acute phase: (Carrion's disease) the most common findings are fever (usually sustained, but with temperature no greater than 102 °F (39 °C)), pallor, malaise, nonpainful hepatomegaly, jaundice, lymphadenopathy, splenomegaly. This phase is characterized by severe hemolytic anemia and transient immunosuppression. The case fatality ratios of untreated patients exceeded 40% but reach around 90% when opportunistic infection with Salmonella spp occurs. In a recent study the attack rate was 13.8% (123 cases) and the case-fatality rate was 0.7%.
The most common findings are bleeding of verrugas, fever, malaise, arthralgias, anorexia, myalgias, pallor, lymphadeopathy, and hepato-splenomegaly.
Diagnosis during the acute phase can be made by obtaining a peripheral blood smear with Giemsa stain, Columbia-blood agar cultures, immunoblot, IFI, and PCR. Diagnosis during the chronic phase can be made using a Warthin-Starry stain of wart biopsy, PCR, and immunoblot.
- synd/3112 at Who Named It?
- Maguiña, C., 1998. Bartonellosis o Enfermedad de Carrión. A.F.A. Editores Importadores S.A., Lima.
- DEVAULT VT (December 1952). "Treatment of bartonellosis with antibiotics". Ann. N. Y. Acad. Sci. 55 (6): 1222–7.
- Ellis BA, Rotz LD, Leake JA, et al. (August 1999). "An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru, 1998". Am. J. Trop. Med. Hyg. 61 (2): 344–9.
- Schultz MG. Daniel Alcides Carrión (photo quiz). Emerg Infect Dis. 2010 Jun. Available from http://www.cdc.gov/EID/content/16/6/1025.htm Accessed 26 May 2010.
- Maco V, Maguiña C, Tirado A, Maco V, Vidal JE (2004). "Carrion's disease (Bartonellosis bacilliformis) confirmed by histopathology in the High Forest of Peru". Rev. Inst. Med. Trop. Sao Paulo 46 (3): 171–4.
- Salinas D La nueva Bartonella Ancashi como causante de la verruga peruana: ¿Cumple los postulados de Koch? Acta Med Per 2014; 31 (1): 34-36
- Maguina C, Garcia PJ, Gotuzzo E, Cordero L, Spach DH (September 2001). "Bartonellosis (Carrión's disease) in the modern era". Clin. Infect. Dis. 33 (6): 772–9.
- Herrer, Arístides (1990). Epidemiología de la verruga peruana. Lima: L. Gonzales-Mugaburu.
- Huarcaya E, Maguiña C, Torres R, Rupay J, Fuentes L (October 2004). "Bartonelosis (Carrion's Disease) in the pediatric population of Peru: an overview and update". Braz J Infect Dis 8 (5): 331–9.
- Oroya fever
- Bartonella bacilliformisHuman Bartonellosis caused by