Ehrlichia chaffeensis

Ehrlichia chaffeensis

Scientific classification
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alpha Proteobacteria
Order: Rickettsiales
Family: Anaplasmataceae
Genus: Ehrlichia
Species: chaffeensis

Ehrlichia chaffeensis is an obligate intracellular[1] gram-negative species of rickettsiales bacteria.[2] It is a zoonotic pathogen transmitted to humans by the lone star tick (Amblyomma americanum).[3] It is the causative agent of human monocytic ehrlichiosis.[4]

Genetic studies support the endosymbiotic theory that a subset of these organisms evolved to live inside mammalian cells as mitochondria to provide cellular energy to the cells in return for protection and sustenance. ATP production in the rickettsia is biochemically identical to that in mammalian mitochondria.

Human monocytic ehrlichiosis caused by E. chaffeensis is known to spread through tick infection primarily in the southern, southcentral and mid-Atlantic regions of the United States.[5] In recent years the lone star tick has expanded its range up the East Coast to New England, putting more humans at risk for tick-borne infections.[6]

It is named for Fort Chaffee where the bacteria was first discovered in blood samples of infected patients.[2]

Transmission Cycle

E. chaffeensis is maintained in nature through a complex zoonotic relationship. The [1] and coyotes.[5]

E. chaffeensis can be transmitted to non-infected tick larvae when feeding on the blood from an infected host.[7] The infection is then maintained and can be transmitted to a reservoir organism or humans at the nymphal stage. Adult ticks can maintain the infection or be infected from feeding on the blood of an infected reservoir organism and may also pass E. chaffeensis to humans or other non-infected reservoir organisms.[1] Transovarial transmission is not known to occur so eggs and unfed larvae are not believed to be infected.[7]


Ehrlichia chaffeensis

E. chaffeensis causes human monocytic ehrlichiosis and is known to infect monocytes.[1] It has also been known to infect other cell types such as lymphocytes, atypical lymphocytes, myelocytes, and neutrophils, but monocytes appear to best harbor the infection.[1]

E. chaffeensis has also been shown to infect canines both naturally[6] and articifially.[8] Symptoms in canine infections are hard to differentiate between E. chaffeensis infection and Ehrlichia canis, which is the species of Ehrlichia that most commonly affects canines.[8]

Signs and Symptoms

Patients display early symptoms within 1 to 2 weeks after tick infection. Early symptoms include fever, headache,[9] malaise, low-back pain, or gastrointestinal symptoms.[3] Some patients may also have myalgias, arthralgias, and an estimated 10-40% of patients may develop coughing, pharyngitis, diarrhea, vomiting, abdominal pain, and changes in mental status.[1]

Diagnosis or Detection

A variety of procedures have been used to detect E. chaffeensis in humans and reservoir organisms. Most commonly serologic testing and PCR amplification are used.[1][3]


E. chaffeensis is susceptible to tetracyclines.[1] Doxycycline treatment is suggested for any patients presenting symptoms of an Ehrlichia infection during the appropriate season and potential tick exposure.[9]

See also


  1. ^ a b c d e f g h i Ganguly, S. (2008). Tick-borne ehrlichiosis infection in human beings. Journal of Vector Borne Disease, 45(4), 273-280. Retrieved from
  2. ^ a b Ehrlichia chaffeensis at the US National Library of Medicine Medical Subject Headings (MeSH)
  3. ^ a b c d Allan, B. F. (2012). Blood meal analysis to identify reservoir hosts for amblyomma americanum ticks. Emerging Infectious Diseases, 16(3), 433.
  4. ^ Schutze GE, Buckingham SC, Marshall GS, et al. (June 2007). "Human monocytic ehrlichiosis in children". Pediatr. Infect. Dis. J. 26 (6): 475–9.  
  5. ^ a b Barker, R. W. (2000). Naturally occurring ehrlichia chaffeensis infection in coyotes from oklahoma. ‘’Emerging Infectious Diseases’’, 6(5), 477.
  6. ^ a b Little, S. E. (2007, January). New developments in managing vector-borne diseases. Retrieved from
  7. ^ a b Long, S. W. (2003). Evaluation of transovarial transmission and transmissibility of Ehrlichia chaffeensis (Rickettsiales: Anaplasmataceae) in Amblyomma americanum (Acari: Ixodidae).Journal of Medical Entomology, 40(6), 1000-1004. doi:
  8. ^ a b Baneth, G. (2010). Ehrlichia and anaplasma infections. Paper presented at World small animal veterinary congress. Retrieved from
  9. ^ a b Baddour, L. M. (2011). Newly discovered ehrlichia species implicated in human infection. Journal Watch Infectious Diseases