Lecithin—cholesterol acyltransferase

Lecithin—cholesterol acyltransferase


Lecithin—cholesterol acyltransferase (LCAT, also called phosphatidylcholine-sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) and low-density lipoproteins in the blood plasma.

Contents

  • Interactive pathway map 1
  • See also 2
  • References 3
  • Further reading 4
  • External links 5

Interactive pathway map

See also

References

Further reading

External links