Phospholipid transfer protein

Phospholipid transfer protein

Phospholipid transfer protein
Symbols  ; BPIFE; HDLCQ9
External IDs ChEMBL: GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.


The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.[1]


PLTP has been shown to interact with Apolipoprotein A1[2] and APOA2.[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 


  1. ^ "Entrez Gene: PLTP phospholipid transfer protein". 
  2. ^ a b Pussinen, P J; Jauhiainen M; Metso J; Pyle L E; Marcel Y L; Fidge N H; Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. (UNITED STATES) 39 (1): 152–61.  

Further reading