SCARB1

SCARB1

Scavenger receptor class B, member 1
Identifiers
Symbols  ; CD36L1; CLA-1; CLA1; HDLQTL6; SR-BI; SRB1
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Scavenger receptor class B member 1 (SRB1) also known as SR-BI is a protein that in humans is encoded by the SCARB1 gene.[1] SR-BI functions as a receptor for high-density lipoprotein.[2]

Scavenger receptor class B, type I (SR-BI) is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. It is best known for its role in facilitating the uptake of cholesteryl esters from high-density lipoproteins in the liver. This process drives the movement of cholesterol from peripheral tissues towards the liver for excretion. This movement of cholesterol is known as reverse cholesterol transport and is a protective mechanism against the development of atherosclerosis, which is the principal cause of heart disease and stroke.

SR-BI has also been identified in the livers of non-mammalian species (turtle, goldfish, shark, chicken, frog, and skate), suggesting it emerged early in vertebrate evolutionary history. The turtle also seems to upregulate SB-RI during egg development, indicating that cholesterol efflux may be at peak levels during developmental stages.[3]

In melanocytic cells SCARB1 gene expression may be regulated by the MITF.[4]

SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus in liver cells.[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

References

  1. ^ "Entrez Gene: SCARB1 Scavenger receptor class B, member 1". 
  2. ^ Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M (January 1996). "Identification of scavenger receptor SR-BI as a high density lipoprotein receptor". Science 271 (5248): 518–20.  
  3. ^ Duggan AE, Marie RS, Callard IP (April 2002). "Expression of SR-BI (Scavenger Receptor Class B Type I) in turtle (Chrysemys picta) tissues and other nonmammalian vertebrates". J. Exp. Zool. 292 (5): 430–4.  
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76.  
  5. ^ Kapadia SB, Barth H, Baumert T, McKeating JA, Chisari FV (January 2007). "Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I". J. Virol. 81 (1): 374–83.  

Further reading

  • Williams DL, Temel RE, Connelly MA (2001). "Roles of scavenger receptor BI and APO A-I in selective uptake of HDL cholesterol by adrenal cells.". Endocr. Res. 26 (4): 639–51.  
  • Krause BR, Auerbach BJ (2001). "Reverse cholesterol transport and future pharmacological approaches to the treatment of atherosclerosis.". Current opinion in investigational drugs (London, England : 2000) 2 (3): 375–81.  
  • Connelly MA, Williams DL (2005). "Scavenger receptor BI: a scavenger receptor with a mission to transport high density lipoprotein lipids.". Curr. Opin. Lipidol. 15 (3): 287–95.  
  • Phillips RW (1978). "The new era in restorative dental materials.". Oper Dent 1 (1): 29–35.  
  • Skre H, Berg K (1974). "Cerebellar ataxia and total albinism: a kindred suggesting pleitotropism or linkage.". Clin. Genet. 5 (3): 196–204.  
  • Calvo D, Dopazo J, Vega MA (1995). "The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution.". Genomics 25 (1): 100–6.  
  • Calvo D, Vega MA (1993). "Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family.". J. Biol. Chem. 268 (25): 18929–35.  
  • Murao K, Terpstra V, Green SR, et al. (1997). "Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes.". J. Biol. Chem. 272 (28): 17551–7.  
  • Ikemoto M, Arai H, Feng D, et al. (2000). "Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I.". Proc. Natl. Acad. Sci. U.S.A. 97 (12): 6538–43.  
  • Husemann J, Silverstein SC (2001). "Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain.". Am. J. Pathol. 158 (3): 825–32.  
  • Li XA, Titlow WB, Jackson BA, et al. (2002). "High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner.". J. Biol. Chem. 277 (13): 11058–63.  
  • Duncan KG, Bailey KR, Kane JP, Schwartz DM (2002). "Human retinal pigment epithelial cells express scavenger receptors BI and BII.". Biochem. Biophys. Res. Commun. 292 (4): 1017–22.  
  • Kawasaki Y, Nakagawa A, Nagaosa K, et al. (2002). "Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells.". J. Biol. Chem. 277 (30): 27559–66.  
  • Qi C, Chang J, Zhu Y, et al. (2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.". J. Biol. Chem. 277 (32): 28624–30.  
  • Johnson MS, Svensson PA, Borén J, et al. (2002). "Expression of scavenger receptor class B type I in gallbladder columnar epithelium.". J. Gastroenterol. Hepatol. 17 (6): 713–20.  
  • Silver DL (2002). "A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver.". J. Biol. Chem. 277 (37): 34042–7.  
  • Bultel-Brienne S, Lestavel S, Pilon A, et al. (2002). "Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteins.". J. Biol. Chem. 277 (39): 36092–9.  
  • Strauss JG, Zimmermann R, Hrzenjak A, et al. (2002). "Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity.". Biochem. J. 368 (Pt 1): 69–79.