Systematic (IUPAC) name
Clinical data
Legal status
CAS number  YesY
ATC code None
Synonyms Cocculine
Chemical data
Formula C19H23NO4 
Mol. mass 329.390 g/mol

Sinomenine or cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis.[1] However, its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine,[2] but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved.[3]

See also


  1. ^ Zhao, ZZ; Liang, ZT; Zhou, H; Jiang, ZH; Liu, ZQ; Wong, YF; Xu, HX; Liu, L (2005). "Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method". Biological & pharmaceutical bulletin 28 (1): 105–9.  
  2. ^ Yamasaki, H (1976). "Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum". Acta medica Okayama 30 (1): 1–20.  
  3. ^ Liu, L; Riese, J; Resch, K; Kaever, V (1994). "Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum". Arzneimittel-Forschung 44 (11): 1223–6.